Summary
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SMILE fruits are created using SAD liquid obtained from Bloodline Elements and only 10% successfully produce artificial devil fruit users.
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The effects of SMILE fruits include improved physical abilities but also the inability to swim and feeling sadness or anger.
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Failed SMILE fruits were distributed to the citizens of Wano, transforming them into Pleasures with negative effects, highlighting the devastating impact of the fruit.
The existence of SMILE Fruit was first introduced during the Punk Hazard story arc. Caesar Clown was the lead scientist behind its creation, using new and existing technologies to ensure mass production.
However, the devastating effects of these fruits would soon be discovered during the Wano Country story arc, in which Kurozumi Orochi orchestrated a malicious plan to distribute the failed fruits to the citizens living in Ebisu City. So, find out what devastating effects SMILE Fruit can produce One piece.

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How SMILE fruits are created
Using SAD it was produced in Dressrosa by the Tontattas
Bow |
Punk Danger |
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Chapters |
654-699 |
Episodes |
579-625 |
The SMILE Devil Fruit is a Zoan-type artificial fruit used to create artificial Devil Fruit users. SMILE is a product of Caesar Clown with assistance from Bloodline Elements. Dr. Vegapunk and Judge Vinsmoke discovered these Brood Elements while part of a “lawless research group”.
The Elements of the Bloodline are the blueprints of life itself, and those who possess the Devil Fruits can study their power; Caesar then expanded on this research by developing a drug called SAD, a crucial ingredient needed to make SMILE.
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SAD liquid is produced by mixing elements from the bloodline of various animals.
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The SMILE Fruit was produced in Dressora, at the SMILE Factory, by the Tontatta dwarves.
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Only one fruit in ten can produce an artificial SMILE Devil Fruit user.
Although Caesar Clown was the lead scientist for the production of the SAD liquid, he also collaborated with Donquixote Doflamingo, who sold and distributed the SMILE fruit to, at the time, one of the Four Emperors, Kaido of the Beast Pirates, with the SMILE Fruits, Kaido planned to equip his Beast Pirate crew with artificially Zoan-type fruit users.

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The collaboration between Doflamingo and Caesar worked perfectly, as Caesar went on to create the SAD liquid on Punk Hazard; Doflamingo used his influence to protect him and the production of the product. In exchange, Doflamingo would get a shipment of SAD liquid, which he would use in his SMILE factory on Dressrosa. This factory was located in a hidden building on the island, where Tontatta dwarves were used as slaves to grow the fruit.
We have successfully recreated a devil fruit!
After the fruits would be harvested, they would be sold to Kaido for his use in the growth of the Animal and Beast Kingdom. However, since the artificial devil fruit was not a complete success, it came with some failures. While Kaido and his subordinates distributed the fruit, only those who were worthy of eating it were given the chance to become artificial Zoan users, called Gifters.
As previously mentioned, for every ten fruits, only one can gift a user with the powers of the SMILE fruit; those who received disaster were called Pleasures, as they only received the negative effects of the SMILE fruit. However, Trafalgar Law destroyed the factory that produced the SAD liquid, thus halting the production of SMILE Fruit, although the fruit's devastating effects remain.
What devastating effects does the SMILE fruit have?
Only 10% of SMILE fruits are successful; the remainder consist exclusively of negative effects
Before considering the actual application of the SMILE fruit and its effects, producing this artificial devil fruit was equally devastating. With the production of this fruit, many were put into slavery by Doflamingo and Caesar Clown. Unfortunately, the Tontatta dwarves were naive and easily believed whatever lies Doflamingo told to ensure the production of SMILEs in their capable hands. Only after the Straw Hats helped them destroy the factory were they freed from the abuse.

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A successful SMILE Devil Fruit will give the user the artificial abilities of an animal, as it is limited to Zoan types. With this, the user will get enhanced physical abilities and attributes of the animal inside the fruit. Like Devil Fruits, users of the SMILE fruit will also be unable to swim after consuming the fruit. However, only 500 SMILE fruits were successful, leaving many failures.
Due to the incomplete formula… As a side effect they also lose the ability to become sad or angry. They can therefore only smile and laugh…!!
As mentioned above, they were called Pleasures and only received the negative effects of the SMILE fruit: the inability to swim and the ability to become sad or angry. Considering the serious side effects of this artificial devil fruit, those who consume it are aware of its properties and negative effects if the fruit does not choose it.
However, this is not where the devastating effects of artificial fruit are truly demonstrated. As if to further punish the citizens of Wano Town, Kurozumi Orochi distributed the half-eaten and failed SMILE Devil Fruit to the citizen farmers residing in Ebisu Town. Since only one bite is needed to gain the abilities within the SMILE Fruit, like the Devil Fruit, after the failed fruits were thrown away, Orochi distributed them to the citizens, turning them into Pleasures.
As a result, when citizens eat these failed fruits to satisfy their hunger, they will suffer all the negative effects of these failed fruits. While the production of an artificial devil fruit has had some success, with 10% of the fruits produced creating an artificial Zoan-type user, the most negative effects exceed this 10%. Since this fruit was not reserved only for the Beast Pirates, the distribution of the failed SMILE fruits led to devastating effects as there was no cure for those affected.
One piece can be streamed on Crunchyroll.

One Piece is a Japanese manga written and illustrated by Eiichiro Oda. The series follows protagonist Monkey D. Luffy and his crew of Straw Hat Pirates as they explore the Grand Line to find the Pirate King's final treasure, One Piece, to become the next king. The manga's popularity helped it grow into a larger media franchise, including an anime with more than 1,000 episodes.
- Seasons
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20
- Number of episodes
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1122